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Myxoid dermatofibrosarcoma protuberans
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Case of the Week #132

Case of the Week #132

Case of the Week #132

Typical example of a myxoid dermatofibrosarcoma protuberans.

Extraskeletal myxoid chondrosarcoma with an abundant myxoid matrix.

Dermatofibrosarcoma protuberans

Steven Billings, MD on Twitter: "Myxoid DFSP: evenly spaced spindled to stellate cells in myxoid stroma, lacks storiform pattern #dermpath #pathology ...

Myxoid dermatofibrosarcoma protuberans (×40). | Download Scientific Diagram

Dermatofibrosarcoma protuberans

Courtesy of Mark R. Wick, M.D.

Fig. 2. Superficial angiomyxoma (×100). A strand of squamous epithelium

Hematoxylin-eosin staining of tissue from a patient with dermatofibrosarcoma protuberans of the breast. (A) Tumor growth into the skin demonstrated a zone ...

Dermatofibrosarcoma protuberans · Dermatofibrosarcoma protuberans · Dermatofibrosarcoma protuberans ...

Low-grade fibromyxoid sarcoma with alternating fibrous and myxoid areas.

Figure 2. The tumor showed the characteristic storiform pattern (H&E, x 40)

DERMATOFIBROSARCOMA PROTUBERANS. IHC: +CD34. NB: myxoid area w/ prominent vessels; elsewhere conventional pattern.pic.twitter.com/8dpMOoB4Kb

Figure 5: Areas of myxoid change along with a capillary

Myxoinflammatory fibroblastic sarcoma with a myxoid background.

Dermatofibrosarcoma protuberans · Dermatofibrosarcoma protuberans ...

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Note the characteristic storiform pattern seen in DFSP.

Figure 3. Myoid nodule centred along a blood vessel (H&E, x 40)

Dermatofibrosarcoma protuberans#

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3:03 PM - 18 Mar 2018

Figure 2

Typical example of a myxoid dermatofibrosarcoma protuberans. | Download Scientific Diagram

Figure 3: DFSP: Tissue section from the tumor showed spindle cells in fascicles, long sweeping bundles arranged in focal storiform as well as herringbone ...

Darkly stained but uniform oval cells immersed in a myxoid and lipomatous stroma. Capillary vasculature is abundantly present.

Residual fat cells are in linear arrangement resembling a string of pearls, characteristic of DFSP but not benign fibrous histiocytoma

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... areas of conventional DFSP too. Pics from myxoid review paper by me & @NRiddleMD: http://www.sciencedirect.com/science/article/pii/S1756231716300135 …

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Small uniform cells radiating like pinwheels from central area that has a blood vessel is characteristic

Figure 1: Hematoxylin-eosin staining of the tumor showed a typical storiform pattern of spindle cells, magnification=100×.

... cutaneous neoplasms: a useful marker in differentiating superficial acral fibromyxoma from dermatofibrosarcoma protuberans | Modern Pathology

Myxofibrosarcoma with a myxoid stroma containing spindle or.

Figure 13.8 Myxoid dermatofibrosarcoma protuberans. (a,b) Prominent blood vessels. Focal mucinous pools. Pseudovascular space lined by mildly atypical tumor ...

Brendan Dickson, MD on Twitter: "DERMATOFIBROSARCOMA PROTUBERANS. IHC: +CD34. NB: myxoid area w/ prominent vessels; elsewhere conventional pattern.… "

... Download full-size image. Figure 12. The uniform growth of a myxoid dermatofibrosarcoma protuberans.

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... proliferation of a uniform population of fibroblasts arranged in a distinct storiform pattern around vascular channels. (b) Photomicrograph shows myxoid ...

Figure 5. Histopathology image showing dermatofibrosarcoma protuberans.

Dermatofibrosarcoma Protuberans variedad convencional, neoplasia fusocelular con patrón en haces cortos que se entrecruzan formando rehiletes (Hematoxilina ...

Figure 10: Immunohistochemical staining with CD34

Figure 32-8 Myxoid dermatofibrosarcoma protuberans (DFSP). This DFSP shows a myxoid appearance as it extends into subcutis. Myxoid change is more common in ...

FIGURE 7.2.4 Fibrosarcomatous change within a DFSP is characterized by replacement of the storiform pattern with a “herringbone” type of pattern.

Dermatofibro-sarcoma Protuberans

Figure 3: Histopathology revealing mitoses less than 5 per 10 high power fields which differentiated from dermatofibroma (H and E, ×400)

Histologic features of myxoid dermatofibrosarcoma protuberans at × 4 (a) and × 10 (b), and superficial acral fibromyxoma at × 4 (c) and × 10 (d).

Figure 2: Spindle-shaped tumor cells in mitosis were visible, magnification=400×.

Figure 8: Histopathology of tumor showing spindle cells with plump nuclei arranged in storiform pattern along with multiple mitotic figures

Ring chromosomes occur ...

Myxoid liposarcoma

Dermatofibrosarcoma Protuberans

(H and E, ×100) (b) Lace-like infiltration in subcutaneous fat (c) Myxoid change (d) Verocay body like areas. (H and E, ×400) (e) High power ...

A311538_1_En_48_Fig3_HTML.jpg

Myxoid liposarcoma pathology

Breast skin

Myxoid DFSP: evenly spaced spindled to stellate cells in myxoid stroma, lacks storiform pattern #dermpath #pathology @dermpedia @ASDPTweetspic.twitter.com/ ...

There are several variants of dermatofibrosarcoma protuberans ...

Bednar tumour: an infrequent diagnosis

Figure 13.6 Borders of dermatofibrosarcoma protuberans. (a) Myxoid dermal surface component. (b) A smooth border to collagenized dermis.

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Dermatofibrosarcoma protuberans (DFSP) with tight storiform growth pattern

Dermatofibrosarcoma protuberans pathology

Why DFSP occurs only in the skin and not in other organs in which fibrocytes are present is an unanswered question.

Fig. 11

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Figure 2: (a) Storiform areas with increased cellularity (b) Focal herring bone pattern (c) Increased mitosis. (H and E, ×400) (d) Focal fuschinophilic ...

Intradermal nodular proliferation of bland spindle cells arranged in loose fascicles and bundles and embedded in a myxoid stroma (H&E, ...

Immunohistochemical examination of tissue from a patient with dermatofibrosarcoma protuberans of the breast (200x). (A) Strong and diffuse staining for CD34 ...

Metastatic dermatofibrosarcoma protuberans: A rare case report from North India Mahajan B B, Sumir K, Singla M - J Can Res Ther

Nodular fasciitis

Storiform pattern of DFSP (100x, H and E)

Dermatofibrosarcoma protuberans (2) recurrence.JPG

Figure 3: Extraskeletal myxoid chondrosarcoma with an abundant myxoid matrix containing round or slightly elongated cells with small hyperchromatic nuclei.

Dermatofibrosarcoma protuberans#

Diseases related to Dermatofibrosarcoma Protuberans

Multiple morphologies of DFSP occurring in distal extremities and acral locations-(A) shows

Classic DFSP, characterized by an irregular pink to brown nodule, which appears scar-like.

(B) In addition to the typical storiform pattern, prominent myxoid stromal changes were demonstrated (H&E, ×100).

Myxoid Melanoma

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Figure 2: Densely packed, monomorphous, plump spindle cells arranged in a storiform pattern

Often have areas of conventional DFSP too. Pics from myxoid review paper by me & @NRiddleMD: https://buff.ly/2FKJBNJ #pathology #BSTpathpic.twitter.com/ ...

FIGURE 7.2.4 Fibrosarcomatous change within a DFSP is characterized by replacement of the storiform pattern with a “herringbone” type of pattern.

Figure 2. In some areas, the neoplastic cells are arranged in elongated parallel and storiform fascicles.

A273500_1_En_2_Fig7_HTML.jpg. Fig. 2.7. Dermatofibrosarcoma protuberans.

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Figure 2i. The Bednar tumor was first described in 1957. They represent less than 5% of DFSPs. At low power, a low-grade fibrosarcomatous pattern and ...

Figure 3 Histopathology of the lesion showing monomorphic spindle cells interlaced in the dermis, with elongated nuclei and extending into the subcutaneous ...

A273500_1_En_2_Fig6_HTML.jpg. Fig. 2.6. Dermatofibrosarcoma protuberans.

Detection of chromosomal translocation t(17;22)(q22;q13) in paraffin-embedded tissue from a patient with dermatofibrosarcoma protuberans of the breast using ...